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Posts Tagged ‘Parkinson disease’

Parkinson disease (PD) is a generative disease of the central nervous system whose main feature is the progressive death of neurons in a part of the brain called the substantia nigra pars compacta. The most important impact of this neuronal loss is a marked decrease in cerebral availability of dopamine, the main substance synthesized by these neurons, causing a malfunction in the regulation of key brain structures involved in movement control.

What are its causes?

No one knows what causes this disease. Recently discovered the existence of genetic abnormalities in some families where most members were affected and familial cases of Parkinson’s disease occurred early (age of onset below 40 years). However, most patients with sporadic Parkinson’s have a presentation that is no clearly identified genetic factors. Read the rest of this entry »